Hyperinflammation

Definition

Hyperinflammation is an excessive and prolonged inflammatory response in the body that can cause damage to tissues and organs.

Scientific / Technical Definition

Hyperinflammation refers to an overactive immune response characterized by the extensive release of pro-inflammatory cytokines, chemokines, and other mediators. This often leads to a pathological inflammatory state that contributes to various diseases and conditions, such as sepsis, acute respiratory distress syndrome, and chronic inflammatory diseases.

Benefits

• While inflammation is a natural part of the immune response, hyperinflammation itself does not carry direct benefits. However, understanding hyperinflammation can help in managing and mitigating its consequences, leading to better health outcomes and reduced risk of tissue damage.

Examples

• Acute inflammatory responses that don't resolve properly can lead to hyperinflammation.
• Chronic infections or autoimmune diseases often exhibit hyperinflammatory traits.

Additional Information

• effects: Hyperinflammation can lead to severe consequences, including tissue damage, organ failure, and can exacerbate conditions like sepsis and severe respiratory infections.

Related Terms

• Inflammation
• Cytokine storm
• Immunomodulation
• Chronic inflammation

References

• Hyperinflammation and What It Means for Your Health
• Cytokine Storm and Hyperinflammation