Pro-inflammatory Cytokines
Definition
Pro-inflammatory cytokines are substances secreted by certain cells of the immune system that promote inflammation. They play a vital role in regulating the immune response and are involved in the development of inflammatory conditions.
Scientific / Technical Definition
Pro-inflammatory cytokines are signaling molecules, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6), produced by macrophages, neutrophils, and other immune cells that contribute to the promotion and maintenance of inflammation in response to infection, injury, or disease. They are crucial in the immune system's response to pathogens and the regulation of immune cell activity.
Benefits
- They help the body respond to infections and injuries by activating the immune system.
- They facilitate wound healing by attracting immune cells to the site of damage.
Examples
- TNF-α
- IL-1
- IL-6
Additional Information
- Effects: Pro-inflammatory cytokines are essential for initiating an immediate immune response, but chronic elevations are associated with inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and cardiovascular disease.
References
Last updated: 10/19/2024