Autophagy

Definition

Autophagy is the body's way of cleaning out damaged cells, in order to regenerate newer, healthier cells.

Scientific / Technical Definition

Autophagy is a regulated, catabolic process wherein cellular components are degraded through lysosomal machinery. This process plays a critical role in removing misfolded or aggregated proteins, clearing damaged organelles such as mitochondria, and combating intracellular pathogens.

Benefits

• Promotes cellular cleanup and recycling processes.
• Enhances longevity and may extend lifespan.
• Supports homeostasis and cellular health.
• Improves metabolic efficiency.
• May aid in preventing neurodegenerative diseases.

Examples

• Fasting initiates autophagy.
• Ketogenic diet can promote autophagy.

Additional Information

• Effects: Autophagy is crucial for cell growth, development, and maintenance and affects conditions such as cancer, neurodegenerative diseases, and infections.

Related Terms

• Intermittent Fasting

References

• Autophagy: physiology and pathophysiology
• Mechanisms and consequences of autophagy