Ketogenesis

Definition

Ketogenesis is a metabolic process where the body produces ketone bodies from fatty acids, usually occurring when carbohydrate intake is low and fat becomes the main source of energy.

Scientific / Technical Definition

Ketogenesis is the biochemical process in which the liver converts fatty acids into ketone bodies, specifically acetoacetate, beta-hydroxybutyrate, and acetone, as a result of prolonged fasting, carbohydrate restrictive diets, or in untreated type 1 diabetes. This process ensures energy supply to tissues, particularly the brain, when glucose is not readily available.

Benefits

• Supports brain function during low carbohydrate intake
• May aid in weight loss by promoting fat oxidation
• Helps manage blood sugar levels
• Potential therapeutic benefits for neurological disorders

Examples

• Prolonged fasting leading to increased ketone production
• Low-carbohydrate ketogenic diets inducing ketogenesis

Additional Information

• Effects: Ketogenesis allows the body to utilize fat as a primary energy source, leading to the production of ketone bodies which can be used by many tissues, including the brain, as an alternative to glucose.

Related Terms

• Ketosis
• Ketone Bodies
• Gluconeogenesis
• Fatty Acid Oxidation

References

• Physiological Regulation of Ketone Body Metabolism
• The Biochemistry of Ketogenesis and Ketolysis