Proton Pump Inhibitors

Definition

Proton pump inhibitors (PPIs) are medications that reduce the amount of acid produced in the stomach, commonly used to treat conditions like acid reflux and stomach ulcers.

Scientific / Technical Definition

Proton pump inhibitors are a class of drugs that work by irreversibly inhibiting the action of the hydrogen/potassium ATPase enzyme system of the gastric parietal cells, significantly reducing gastric acid secretion. They are widely used in the management of gastroesophageal reflux disease (GERD), Zollinger–Ellison syndrome, and peptic ulcer disease.

Benefits

• Reduction of gastric acid secretion
• Relief from symptoms of heartburn and acid reflux
• Promotion of healing in peptic ulcer disease
• Prevention of esophagitis

Examples

• Omeprazole (Prilosec)
• Lansoprazole (Prevacid)
• Esomeprazole (Nexium)
• Pantoprazole (Protonix)

Additional Information

• Known issues: Long-term use of PPIs can lead to potential side effects like vitamin B12 deficiency, kidney disease, and increased risk of bone fractures.

Related Terms

• Gastroesophageal Reflux Disease
• Antacids
• H2 Blockers
• Stomach Ulcers
• Digestion

References

• Proton Pump Inhibitors - A Review of Benefits and Risks
• Long-term Use of Proton Pump Inhibitors: Balancing Potential Benefits and Harms