Mtor Signaling Pathway

Definition

The MTOR signaling pathway is a central regulator of cell growth, muscle protein synthesis, and nutrient metabolism in the body.

Scientific / Technical Definition

The mechanistic target of rapamycin (MTOR) signaling pathway is a crucial cellular pathway that regulates processes such as protein synthesis, cell growth, autophagy, and metabolism in response to nutrients, growth factors, and cellular energy status. It integrates signals from insulin, growth factors, amino acids, and mechanical stress to modulate anabolic and catabolic processes.

Benefits

• Supports muscle growth and repair.
• Aids in cell growth and survival.
• Regulates protein synthesis in response to nutrient availability.
• Helps in adapting to hypoxic or energetic stress.
• Improves mitochondrial function and oxidative metabolism.

Examples

• Leucine-rich foods such as beef, chicken, fish, and soybeans stimulate the MTOR pathway.
• Adequate protein intake from various sources can support the pathway.
• Resistance training combined with protein consumption activates the MTOR pathway.

Additional Information

• Importance: This pathway is important for integrating physiological inputs to control growth-related processes, making it a pivotal point in understanding diseases like cancer, diabetes, and neurodegenerative disorders.

Related Terms

• Protein Synthesis
• Muscle Hypertrophy
• Anabolism
• Rapamycin
• Amino Acids

References

• Mechanistic Target of Rapamycin (MTOR) - An Overview
• Role of MTOR in Nutrient Sensing and Cellular Metabolism