Inflammatory Mediators
Definition
Inflammatory mediators are substances released by the immune system to help fight infections and repair tissues, but they can also contribute to inflammation-related diseases if not regulated properly.
Scientific / Technical Definition
Inflammatory mediators are a group of biologically active substances released primarily by immune cells. These include cytokines, chemokines, eicosanoids, and other small molecules that are involved in the initiation, regulation, and perpetuation of inflammatory responses. They play crucial roles in the body's defense mechanisms but are also implicated in the development of chronic inflammatory diseases, including cardiovascular diseases.
Benefits
- They help in defending the body against pathogens.
- Assist in the repair of damaged tissues.
- Mediate the acute inflammatory response to healing injuries.
Examples
- Cytokines such as interleukins and tumor necrosis factor (TNF).
- Eicosanoids such as prostaglandins and leukotrienes.
- Histamines released during allergic reactions.
Additional Information
- Effects: Inflammatory mediators can contribute to chronic inflammation if the immune response is excessive or prolonged, potentially leading to cardiovascular diseases, metabolic disorders, and other chronic health conditions.
References
Last updated: 10/26/2024